Chemometric Optimization of the Ruthenium Carbonyl Catalysed Cyclization of 2-Nitrostilbene to 2-Phenylindole
نویسندگان
چکیده
A chemometric optimization of the Ru,(CO), catalysed deoxygenation of 2-nitrostilbene to 2-phenylindole was carried out. The effects of temperature, CO pressure, amounts of catalyst and substrate on conversion and selectivity were examined by factorial design/response surface methods. The conversion was found to increase on increasing the temperature and decreasing the CO pressure, it assumed a minimum value for medium amounts of catalyst and was almost independent of the amount of substrate. These results were also confirmed using a learning system and were used to develop a mechanism for the reaction. The data suggest two different mechanisms: one based on a Ru(CO), catalysed process and another one based on a Ru,(CO),, catalysed process, which are first and zero order with respect to the substrate, respectively.
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